Prototype Nutrition Ketoforce



The Weak Muscle Panacea?

By Patrick Arnold

My blog was never intended to be a forum for which to discuss (promote?) products that I sell, but this week I am going to make an exception because I think the subject matter is quite interesting nonetheless. I know it may sound a bit like sales promo piece (at the end especially) – and it kind of is – but since what I am discussing here is something truly remarkable and not the typical crap you usually see I don’t feel so guilty about it

The product is Creatinol-O-Phosphate (COP) . No, this is NOT creatine I am talking about, it is a completely different chemical compound. Anyway, I ran across the literature on COP about 8 years ago and was quite impressed. It is very well studied and its effects, as well as safety, on humans is quite well documented. COP has been a drug in Italy for several decades where it is generally prescribed to strengthen the heart muscle in patients with coronary diseases. In addition to its positive effects on heart muscle, COP has also been shown to have quite significant influences on skeletal muscle as well – increasing both strength and endurance.

The mechanisms behind the actions of COP on muscle have been discussed in the literature but no clear indication of exactly how it works has been found. COP definitely increases levels of ATP in the muscle, and this may be due in part because of its actions as a intracellular buffer, a phosphate donor, or a stabilizer of cell membranes. Whatever the mechanisms are, the end result is that contractility (force of contraction) of muscles is increased – especially in hypoxic / ischemic (low oxygen, low blood flow) conditions.

Hypoxia / ischemia of heart muscle tissue is the core problem for patients with heart disease, and it is due to reduced blood supply and/or damaged and scarred muscle tissue. Hypoxia / ischemia is also extremely relevant to athletes who challenge their muscles with aggressive activities – such as weight lifting. Everytime you do a set and your muscles start to burn and you get weaker that is hypoxia / ischemia setting in. Lactic acid goes up, muscle pH drops, and ATP levels plummet. The result is muscle failure and a sort of cellular “rigor mortis”. This whole phenomenon also comes into play in the case of musculoskeletal injuries and aches and pains. Chronic heavy training leads to scar tissue build up which can impede blood flow and nerve transmission. Muscles ache more than they should, tighten up, and performance is compromised. This is low level constant hypoxia/ischemia as opposed to what happens at the end of a set (which is acute and transient), but the same priniciples lie at the heart of both.

So let me get back to my experiences with COP. My first experiences were with an injectable form which was modeled after what is sold in Italy (an oral form is sold there too but the injectable is more commonly prescribed.) This injectable form was used by many competitive and non-competitive athletes and the results were consistent and remarkable. Greater strength, recovery, and endurance were commonplace. And most striking were reports of rapid pain relief of chronic muscle pain and even some arthtitic type pain. For several people this effect was dramatic. All these effects were totally consistent with the purported anti-hyopxic/ischemic properties of COP on muscle. It was quite apparent that this stuff was the real deal.

This was all 7 or 8 years ago. Since then COP has appeared on the supplement market. Obviously it appeared in oral form and not the injectable form that the people I mentioned had been using. The companies that started selling COP I noticed were putting it in multi-ingredient formulas at doses way too low to be effective at all however. To date, nobody to my knowledge has ever put out a fully dosed effective COP product. You see, the injectable version required at least one gram a day to really work. And according to the literature, oral COP has 60% bioavailability. Consequently one probably needs at least 2 grams a day of oral COP to really begin to see its benefits.

Its for this reason that I formulated an effervescent COP. The reason why I made it effervescent is because my experience with oral COP is that taking it straight leads to some gastrointestinal discomfort and this is greatly relieved when it is formulated in a more soluble effervescent form. Since my product contains nothing but COP and is priced modestly it allows people to try the stuff out in the daily multi-gram doses that one needs to take for it to really be effective. So if you find what I wrote here interesting and want to try the stuff out you can go to here . and purchase some. Please feel free to offer me any feeback you might have from the stuff as I am eager to here. You can use the customer service contact. Thanks

17 Responses so far

Hi Patrick!

Sounds like a very interesting compound. Unfortunately, the abstracts for studies on COP are seriously lacking on Pubmed, and the only other info I can dig up on it is from other supplement companies.

Could you point me in the direction of some of the studies and the anecdotal feedback you mentioned?



basically effects are similar to those from MusleTech Aplodan, as example? Leaving out draining effects such behaviour has for pocket:D

(as I remember vaguely, COD is the main ingredient inside Aplodan)


Pogue, try google scholar. you just do a google search and click on the “more” link at top and scroll down and hit scholar. As far as the anecdotal feedback i mention in my blog you are not going to find that written anywhere. The people i refer to are private individuals outside of the internet world and for whom anonymity is paramount

nobody knows how much COP is in aplodan but it is almost certainly less than a gram. It also contains alpha lipoic acid

Patrick, I’ve always admired your ingenuity, pioneering attitude etc. so I’m psyched about trying this product, especially for two reasons. One, I enjoy yoga and pilates, but the static holds and isometric contractions build up tons of lactic acid. I usually start cramping up, charlie-horsing and have to cut sessions short because of this. Two, in general I would say I suffer from chronically tight and tense muscles. With that tension comes limited blood flow, waste disposal, etc, so anything that might help in this department is welcomed.

But I have to ask you, what exactly does this product do on a deeper technical level that creatine and/or beta alanine doesn’t do?

Here’s what I’m getting at. I’ve been poking around the net and people have been saying things similar to what you have in this blog post.

For instance “Don’t confuse this compound with creatine, it’s totally different. Instead what it does is aid in replenishing atp levels and increases maximum contraction. Also it … (insert any other benefit found by supplementing with creatine here)”

Or “Don’t confuse this product with Beta Alanine, instead what this product does is it buffers lactic acid within the muscles so that the muscles can sustain longer contractions. Also it…. (also add any other positive attribute of beta-alanine)”

Do you catch my drift? So I’m not a biochemist or I’d probably already know the answer to this, but how does COP manifest its benefits, especially wherein creatine or beta-alanine fall short? Is there anything grossly different about its MOA that makes it more novel? Obviously you believe so, can you tell me what those specific things are?

eclypz you bring up valid points. Yes the effects of cop seem similar to the effects you see from creatine. COP however does not dephosphorylate to any meaningful extent in muscle like creatine does. Therefore it apparently raises ATP levels by a mechanism other than by being a phosphate donor (like creatine does).

Also, COP appears to raise ATP in resting muscle and I am not so sure that beta-alanine does that

So while the end effects are qualitatively similar to creatine and beta alanine to some extent, the mechanism of action of COP may be unique in part compared to these two ergogens. That leaves open the possibility that COP taken along with either one (or both) of these may lead to greater effects than either one taken alone

Hey Patrick,

Are there any known side affects like acne or gyno from taking any of these products on prototypenutrition, like COP or 711?


Jaspaul, there have been no reports of any gyno from any of the products on prototype and it is not an expected side effect. There have been a few reports of slight acne from the 11 spray but still thats rare. all the sprays have the potential to irritate skin for sensitive people


I’ve got your product in my hands now! Like I said, I’ve always seemed to deal with tight, or tense muscles, and things like guaifenesin have helped a lot (it has a mild muscle relaxant properties) especially when it comes to workout recovery. So anything that can help these tight, sore and achey muscles do their thing better, especially in movements that result in a lot of lactic acid buildup, will be awesome for me.

Now if only I can get past the same obstacle I had with Aspartic Acid. You mentioned your product is formulated with effervescence to increase absorption and minimize gastric distress. I need even more help. Perhaps I just need to wait until right after a huge meal so that it will hold. Twice I’ve taken it and had the kind of results you can imagine someone might have if their tummy is sensitive to this type of thing.

Also I’m curious about loading, how long to see results. I notice an instant feeling in my body after taking it, but I get this kind of feeling from sodium bicarbonate and the product seems to have quite a bit of that in it. How long do you think it will take to decide if this product is living up to the excitement for me? Do I need to megadose in order to saturate? Hoping not!!!

If only I could get the raw powder and make an intramuscular product ;) Searched the net for the italian brand name for the medication to see if I could order it online to no avail.

I love supporting the few supp companies I trust out there, but the rate-limiting step of this, d-aspartic acid, and beta alanine seems to be my gastric tolerance!

eclypz you should use one scoop at a time. Some people cant take two scoops at once. And even if you only took one scoop in morning and one at night you still should be taking in enuff COP to make a difference.

We are going to change the labels to reflect this

funny you mention this, I took one scoop this morning, sipped it slowly in my preworkout bcaa cocktail and so far no problems. How long should it take to start seeing things changing?

Is there any particular reason why a transdermal application wasn’t used?

within a week cop should exert its benefits on the muscles.

COP is not really suitable for transdermal application. it has poor solubility in its straight form in both polar and non-polar solvents. In its sodium salt form (which is what you are getting in the effervescent formula) it has good water solubiliity but its lipid (non-polar) solubility is nil. In other words, COP wont diffuse through the skin in any meaningful degree

PA –

Any intentions on supplying larger distributors with the Prototype line?

Also, we need “I Am Infamous” or “I Am Badass” t-shirts.


prototype line keeps our doors open. was never meant to be full blown supplement company. its my “fun” line and its a test marketing vehicle for new products. epharm is our major focus. the effervescent cop may graduate to epharm label along with additoin of some other ingredients to the formula


Would COP help/reduce chronic fatigue syndrome?

COP to the rescue?

Am J Physiol Endocrinol Metab. 2011 Sep 13. [Epub ahead of print]
Leucine or carbohydrate supplementation reduces AMPK and eEF2 phosphorylation and extends postprandial muscle protein synthesis in rats.
Wilson GJ, Layman DK, Moulton CJ, Norton LE, Anthony TG, Proud CG, Rupassara SI, Garlick PJ.

1University of Illinois.

Muscle protein synthesis (MPS) increases after consumption of a protein containing meal, but returns to baseline values within 3h, in spite of continued elevations of plasma amino acids and mammalian target of rapamycin (mTORC1) signaling. This study evaluated the potential for supplemental leucine (Leu), carbohydrates (CHO), or both to prolong elevated MPS after a meal. Male Sprague-Dawley rats (~270 g) trained to consume three meals daily were food deprived for 12 h, and then blood and gastrocnemius muscle collected 0, 90, or 180 min after a standard 4 g test meal (20% whey protein). At 135 min post-meal, rats were orally administered 2.63 g CHO, 270 mg Leu, both, or water (Sham control). Following test meal consumption, MPS peaked at 90 min then returned to basal (time 0) rates at 180 min even though ribosomal protein S6 kinase (S6K1) and eIF4E binding protein-1 (4E-BP1) phosphorylation remained elevated. In contrast, rats administered Leu and / or CHO supplements at 135 min post meal maintained peak MPS through 180 min. MPS was inversely associated with the phosphorylation states of translation elongation factor 2 (eEF2), the “cellular energy sensor” adenosine monophosphate-activated protein kinase alpha (AMPKα) and its substrate, acetyl-CoA carboxylase (ACC), and with increases in the ratio of AMP/ATP. We conclude that the incongruity between MPS and mTORC1 at 180 min reflects a block in translation elongation due to reduced cellular energy. Administering Leu or CHO supplements ~2 h after a meal maintains cellular energy status and extends the postprandial duration of MPS.

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